Mindfulness-based cognitive therapy is associated with distinct resting-state neural patterns in patients with generalized anxiety disorder. Author: Zhao XR1,2, Chen ZF3, Kang CY4, Liu RX5, Bai JY6, Cao YP1, Cheng YQ2, Xu XF2, Zhang YL1 Affiliation: <sup>1</sup>Mental Health Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. <sup>2</sup>Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. <sup>3</sup>Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan, China. <sup>4</sup>Department of Clinical Psychology, East Hospital Affiliated to Tongji University, Shanghai, China. <sup>5</sup>Department of Clinical Psychology, The Second People's Hospital of Yunnan Province, Kunming, Yunnan, China. <sup>6</sup>Department of Geriatrics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. Conference/Journal: Asia Pac Psychiatry. Date published: 2019 Jul 28 Other: Volume ID: e12368 , Special Notes: doi: 10.1111/appy.12368. [Epub ahead of print] , Word Count: 256 INTRODUCTION: Mindfulness-based cognitive therapy (MBCT) may be effective for generalized anxiety disorder (GAD); however, the neural mechanism is poorly understood. In this study, we examined the potential neural mechanisms through which MBCT may reduce anxiety in patients with mild-to-moderate GAD. METHODS: Eight weekly group MBCT sessions (2 h each) were conducted with 32 GAD patients. Resting-state functional magnetic resonance imaging (fMRI) was used, along with clinical and mindfulness profiles. A regional homogeneity (ReHo) approach was applied, and resting-state functional connectivity in the default mode network (DMN) using the posterior cingulate cortex (PCC) seed was examined. RESULTS: MBCT reduced the anxiety and increased the mindfulness abilities of patients. After MBCT, patients had reduced ReHo in broad regions of the limbic system, along with increased DMN functional connectivity in the anterior cingulate cortex (ACC) and bilateral insula. Overlapping regions of reduced ReHo and increased DMN functional connectivity were observed in the mid-cingulate cortex (MCC) and bilateral insula. The increased PCC-ACC and PCC-insula functional connectivity following MBCT were related to anxiety improvements, suggesting a potential therapeutic mechanism for mindfulness-based therapies. DISCUSSION: Group MBCT treatment appears to have effectively reduced anxiety symptoms in patients with mild-to-moderate GAD. Activation and functional connectivity appeared significantly different across some limbic regions after MBCT treatment. The salience network showed reduced ReHo and increased connectivity to the PCC. The DMN functional connectivity of the MCC may indicate reduced anxiety and improved mindfulness in GAD patients. © 2019 John Wiley & Sons Australia, Ltd. KEYWORDS: functional MRI (fMRI); generalized anxiety disorder; mindfulness-based cognitive therapy (MBCT); waiting list PMID: 31353828 DOI: 10.1111/appy.12368