The Response of Osteoblasts and Bone to Sinusoidal Electromagnetic Fields: Insights from the Literature.


Author: Galli C1, Colangelo M2, Pedrazzi G3, Guizzardi S2

Affiliation: <sup>1</sup>Department of Medicine and Surgery, University of Parma, Parma, Italy. carlo.galli@unipr.it.

<sup>2</sup>Department of Medicine and Surgery, Histology and Embryology Lab, University of Parma, Parma, Italy.

<sup>3</sup>Department of Medicine and Surgery, Neuroscience Unit, University of Parma, Via Volturno 39, 43126, Parma, Italy.
Conference/Journal: Calcif Tissue Int.
Date published: 2019 Apr 17
Other:
  Special Notes: doi: 10.1007/s00223-019-00554-9. [Epub ahead of print]   ,  Word Count: 172  
    Electromagnetic fields (EMFs) have been proposed as a tool to ameliorate bone formation and healing. Despite their promising results, however, they have failed to enter routine clinical protocols to treat bone conditions where higher bone mass has to be achieved. This is no doubt also due to a fundamental lack of knowledge and understanding on their effects and the optimal settings for attaining the desired therapeutic effects. This review analysed the available in vitro and in vivo studies that assessed the effects of sinusoidal EMFs (SEMFs) on bone and bone cells, comparing the results and investigating possible mechanisms of action by which SEMFs interact with tissues and cells. The effects of SEMFs on bone have not been as thoroughly investigated as pulsed EMFs; however, abundant evidence shows that SEMFs affect the proliferation and differentiation of osteoblastic cells, acting on multiple cellular mechanisms. SEMFs have also proven to increase bone mass in rodents under normal conditions and in osteoporotic animals.



KEYWORDS: Cell differentiation; Electromagnetic fields; Osteoblasts; SEMF



PMID: 30997574  DOI: 10.1007/s00223-019-00554-9