Whole body vibration exercise for chronic musculoskeletal pain: A Systematic review and meta-analysis of randomized controlled trials. Author: Dong Y1, Wu W1, Zheng J2, Chen S1, Qiao J3, Wang X4 Affiliation: <sup>1</sup>Department of Treatment, The Second Rehabilitation Hospital of Shanghai, Shanghai, China. <sup>2</sup>Rehabilitation Medical Department, Hua Dong Hospital, Shanghai, China. <sup>3</sup>Department of Treatment, The Second Rehabilitation Hospital of Shanghai, Shanghai, China. Electronic address: qiaojun19791117@126.com. <sup>4</sup>Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China. Electronic address: qiang897@163.com. Conference/Journal: Arch Phys Med Rehabil. Date published: 2019 Apr 17 Other: Pages: S0003-9993(19)30241-2 , Special Notes: doi: 10.1016/j.apmr.2019.03.011. [Epub ahead of print] , Word Count: 337 OBJECTIVE: This study systematically reviews previous work on the effects of whole body vibration exercise (WBVE) on pain associated with chronic musculoskeletal disorders.
 DATA SOURCES: Seven electronic databases (PubMed, Embase, CINAHL, Web of Science, Cochrane, Physiotherapy Evidence and CNKI) were searched for articles published between January 1980 and September 2018.
 STUDY SELECTION: Randomized control trials involving adults with chronic low back pain (CLBP), osteoarthritis (OA) or fibromyalgia were included. Participants in the WBVE intervention group were compared with those in the non-treatment and non-WBVE control groups.
 DATA EXTRACTION: Data were independently extracted using a standardised form. Methodological quality was assessed using the Physiotherapy Evidence Database scale (Pedro). DATA SYNTHESIS: Suitable data from 16 studies were pooled for meta-analysis. A random effects model was used to calculate between-groups mean differences at 95% confidence interval (CI). The data were analysed depending on the duration of the follow-up, common disorders and different control interventions. RESULTS: Alleviation of pain was observed at medium term (standardised mean difference (SMD, -0.67; 95% CI, -1.14 to -0.21; I2, 80%) and long term (SMD, -0.31; 95% CI, -0.59 to -0.02; I2, 0%). Pain was alleviated in OA (SMD, -0.37; 95% CI, -0.64 to -0.10; P < 0.05; I2, 22%) and CLBP (SMD, -0.44; 95% CI, -0.75 to -0.13; P < 0.05; I2, 12%). Long term WBVE could relieve chronic musculoskeletal pain conditions of OA (SMD, -0.46; 95% CI, -0.80 to -0.13; I2, 0%; P < 0.05). WBVE improved chronic musculoskeletal pain compared with the treatment "X" control (SMD, -0.37; 95% CI, -0.61 to -0.12; I2, 26%; P < 0.05), traditional treatment control (SMD, -1.02; 95% CI, -2.44 to 0.4; I2, 94%; P > 0.05) and no treatment control (SMD, -1; 95% CI, -1.76 to -0.24; I2, 75%; P < 0.05). CONCLUSIONS: Evidence suggests the positive effects of WBVE on chronic musculoskeletal pain, long durations of WBVE could be especially beneficial. However, WBVE doesn't significantly relieve chronic musculoskeletal pain compared with the traditional treatment. Further work is required to identify which parameters of WBVE are ideal for patients with chronic musculoskeletal pain. Copyright © 2019. Published by Elsevier Inc. KEYWORDS: Whole body vibration exercise; chronic pain; meta-analysis; musculoskeletal diseases; systematic review PMID: 31004565 DOI: 10.1016/j.apmr.2019.03.011