How whole-body vibration can help our COPD patients. Physiological changes at different vibration frequencies. Author: Pleguezuelos E1,2,3, Casarramona P1, Guirao L1,3, Samitier B1, Ortega P4, Vila X4, Carmen AD1, Ovejero L4, Moreno E5, Serra N5, Gomís M3, Garnacho-Castaño MV3, Miravitlles M6 Affiliation: <sup>1</sup>Physical Medicine and Rehabilitation Department, Mataró Hospital, Barcelona, Spain, epleguezuelos@csdm.cat. <sup>2</sup>Department of Experimental Science and Healthcare, Faculty of Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain, epleguezuelos@csdm.cat. <sup>3</sup>School of Sciences, Tecnocampus-School of Health Sciencies, Pompeu Fabra University, Mataro, Barcelona, Spain, epleguezuelos@csdm.cat. <sup>4</sup>Pneumology Department, Mataró Hospital, Barcelona, Spain. <sup>5</sup>Physical Medicine and Rehabilitation Department, Hospitalet General Hospital, L'Hospitalet de Llobregat, Barcelona, Spain. <sup>6</sup>Pneumology Department, Hospital Universitari Vall d'Hebron, Ciber de Enfermedades Respiratorias (CIBERES), Barcelona, Spain. Conference/Journal: Int J Chron Obstruct Pulmon Dis. Date published: 2018 Oct 18 Other: Volume ID: 13 , Pages: 3373-3380 , Special Notes: doi: 10.2147/COPD.S165058. eCollection 2018. , Word Count: 224 Objective: Evaluate cardiac, metabolic, and ventilatory changes during a training session with whole-body vibration training (WBVT) with 3 different frequencies in patients with chronic obstructive pulmonary disease (COPD). Methods: This was a prospective, interventional trial in outpatients with severe COPD. Participants performed 3 vertical WBVT sessions once a week using frequencies of 35, 25 Hz and no vibration in squatting position (isometric). Cardiac, metabolic, and ventilator parameters were monitored during the sessions using an ergospirometer. Changes in oxygen pulse response (VO2/HR) at the different frequencies were the primary outcome of the study. Results: Thirty-two male patients with a mean forced expiratory volume in 1 second of 39.7% completed the study. Compared to the reference of 35 Hz, VO2/HR at no vibration was 10.7% lower (P=0.005); however, no statistically significant differences were observed on comparing the frequencies of 35 and 25 Hz. The median oxygen uptake (VO2) at 25 Hz and no vibration was 9.43% and 13.9% lower, respectively, compared to that obtained at 35 Hz (both comparisons P<0.0001). The median expiratory volume without vibration was 9.43% lower than the VO2 at the end of the assessment at 35 Hz vibration (P=0.002). Conclusion: Vertical WBVT training sessions show greater cardiac, metabolic, and respiratory responses compared with the squat position. On comparing the 2 frequencies used, we observed that the frequency of 35 Hz provides higher cardiorespiratory adaptation. KEYWORDS: COPD; cardioventilatory response; exercise; whole-body vibration PMID: 30425467 PMCID: PMC6203116 DOI: 10.2147/COPD.S165058