Association between Physical Exercise and Biomarkers of Oxidative Stress among Middle-Aged and Elderly Community Residents with Essential Hypertension in China.


Author: Yu Y1,2, Gao Q1,2, Xia W3, Zhang L4, Hu Z2, Wu X3, Jia X3

Affiliation: <sup>1</sup>Department of Physiology, Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu 233030, China.

<sup>2</sup>Science Research Center, Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu 233030, China.

<sup>3</sup>Department of Epidemiology and Statistics, Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu 233030, China.

<sup>4</sup>Department of Neurology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
Conference/Journal: Biomed Res Int.
Date published: 2018 Jul 3
Other:
 Volume ID: 2018   ,  Pages: 4135104   ,  Special Notes: doi: 10.1155/2018/4135104. eCollection  2018.   ,  Word Count: 237  
    This study aimed to investigate the role of different types and frequencies of physical exercise in biomarkers of oxidative stress among middle-aged and elderly community residents with essential hypertension in China. A community-based cross-sectional survey was undertaken in 7 subdistricts. Individuals, 45-79 years old, with essential hypertension (n = 402) and without cardiovascular disease (n = 1047) were included. Superoxide dismutase (SOD) activities and plasma levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) were determined. Multilevel linear regression was used to estimate the associations between various types of physical exercise and oxidative stress biomarker levels. Participants engaged in high frequency walking/square dancing or taiji/yoga demonstrated decreased systolic blood pressure in both groups; however, diastolic blood pressure decreased only among individuals with hypertension participating in walking/square dancing. In individuals with hypertension, MDA levels decreased in those participating in walking/square dancing, SOD activity increased in those participating in walking/square dancing, and 4-HNE levels decreased in those involved in taiji/yoga. In individuals without cardiovascular disease, MDA levels decreased in those involved in walking/square dancing or taiji/yoga, SOD activity increased in those performing walking/square dancing, and 4-HNE levels decreased in those involved in taiji/yoga. Oxidative stress marker levels also improved in those involved in walking/square dancing or taiji/yoga groups as the exercise frequency increased. Thus, frequent participation in walking/square dancing or taiji/yoga effectively decreases hypertension-related oxidative stress biomarker levels.



PMID: 30065938 PMCID: PMC6051290 DOI: 10.1155/2018/4135104