Altered topological patterns of brain functional networks in Crohn's disease.


Author: Liu P1,2, Li R3,4, Bao C5, Wei Y3,4, Fan Y3,4, Liu Y3,4, Wang G3,4, Wu H6, Qin W7,8

Affiliation: <sup>1</sup>Life Sciences Research Center, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, China. liupengphd@gmail.com.

<sup>2</sup>Engineering Research Center of Molecular-imaging and Neuro-imaging, Ministry of Education, Xi'an, People's Republic of China. liupengphd@gmail.com.

<sup>3</sup>Life Sciences Research Center, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.

<sup>4</sup>Engineering Research Center of Molecular-imaging and Neuro-imaging, Ministry of Education, Xi'an, People's Republic of China.

<sup>5</sup>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.

<sup>6</sup>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China. wuhuangan@126.com.

<sup>7</sup>Life Sciences Research Center, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, China. wqin@xidian.edu.cn.

<sup>8</sup>Engineering Research Center of Molecular-imaging and Neuro-imaging, Ministry of Education, Xi'an, People's Republic of China. wqin@xidian.edu.cn.
Conference/Journal: Brain Imaging Behav.
Date published: 2018 Jan 3
Other:
  Special Notes: doi: 10.1007/s11682-017-9814-8. [Epub ahead of print]   ,  Word Count: 267  
    Crohn's disease (CD) has been reported to relate with the functional and structural alterations in several local brain regions. However, it remains unknown whether the possible abnormalities of information transmission and integration between brain regions are associated with CD. The purpose of this study was to investigate the topological alterations of brain functional networks and the potential relationships between the neuroimaging findings and CD clinical characteristics. 43 remissive CD patients and 37 matched healthy controls (HCs) were recruited to obtain their resting-state functional magnetic resonance imaging (fMRI) data. Independent component analysis was applied to decompose fMRI data for building brain functional networks. The local and global topological properties of networks and connectivity of brain regions were computed within each group. We then examined the relationships between the topological patterns and CD clinical characteristics. Compared to HCs, CD patients exhibited disrupted local and global topological patterns of brain functional networks including the decreased nodal graph metrics in the subcortical, sensorimotor, cognitive control and default-mode networks and dysfunctional interactions within and among these four networks. The connectivity strength of putamen negatively correlated with CD duration in patients. Moreover, CD patients with high level of anxiety and/or depression had altered local topological patterns associated with anterior cingulate cortex (ACC), medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC) compared to other patients. By revealing CD-related changes in topological patterns of brain functional networks, our findings provide further neuroimaging evidence on the pathophysiology of CD involved in pain, sensory, emotional and/or cognitive processing.



KEYWORDS: Brain functional network; Crohn’s disease; Magnetic resonance imaging; Topological alterations



PMID: 29297154  DOI: 10.1007/s11682-017-9814-8