Pulsed electromagnetic field at different stages of knee osteoarthritis in rats induced by low-dose monosodium iodoacetate: Effect on subchondral trabecular bone microarchitecture and cartilage degradation.


Author: Yang X1,2, He H1,2, Zhou Y3, Zhou Y1,2, Gao Q1,2, Wang P1,2, He C1,2,3

Affiliation: <sup>1</sup>Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China.

<sup>2</sup>Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, China.

<sup>3</sup>Institute for Disaster Management and Reconstruction of Sichuan University and Hong Kong Polytechnic University, Chengdu, China.
Conference/Journal: Bioelectromagnetics.
Date published: 2016 Dec 27
Other:
  Special Notes: doi: 10.1002/bem.22028. [Epub ahead of print]   ,  Word Count: 233  
    The aim of the study was to investigate the efficacy of pre-emptive, early, and delayed pulsed electromagnetic field (PEMF) treatment on cartilage and subchondral trabecular bone in knee osteoarthritis (OA) rats induced by low-dose monosodium iodoacetate (MIA). Seventy-five 12-week-old male Sprague-Dawley rats were assigned to five groups: OA (n = 30), pre-emptive PEMF (n = 10), early PEMF (n = 10), delayed PEMF (n = 10), and control (n = 15). Osteoarthritis was induced by injecting 0.2 mg MIA in rat's right knee joint. Control rats received a single sterile saline injection in the right knee. Male rats received pre-emptive (n = 10, day 0-end of week 4), early (n = 10, end of week 4-end of week 8), or delayed (n = 10, end of week 8-end of week 12) PEMF treatment (75 Hz, 1.6 mT). After 4, 8, and 12 weeks, rats were sacrificed at each time point and right knees were harvested. After sacrifice, micro-computed tomography, histology, and biomarker analyses were performed. We found pre-emptive PEMF treatment preserved subchondral trabecular bone microarchitecture and prevented subchondral bone loss in MIA-induced OA rat model. Early and delayed PEMF treatment maintained subchondral trabeculae. PEMF treatment increased bone and cartilage formation, and decreased bone and cartilage resorption. Pre-emptive and early PEMF treatment had moderate effects on cartilage degradation. Time point of treatment initiation is crucial for treating OA. PEMF might become a potential biophysical treatment modality for osteoarthritis. Bioelectromagnetics. 2016;9999:XX-XX. © 2016 Wiley Periodicals, Inc.



© 2016 Wiley Periodicals, Inc.



KEYWORDS: X-ray microtomography; cartilage; osteoarthritis; pulsed electromagnetic field; subchondral bone



PMID: 28026095  DOI: 10.1002/bem.22028