Brain magnetic stimulation in animal models: a valuable lesson for clinical applications.


Author: Escribano BM1, Santamaría A2, De Lima ME3, De Lima M4, Escribano BM1, Santamaría A5, De Lima ME6, Bashir S7, Túnez I8

Affiliation: <sup>1</sup>Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), Cordoba, Spain..

<sup>2</sup>3Laboratory of Excitatory Amino Acids, National Institute of Neurology and Neurosurgery, Mexico City, Mexico..

<sup>3</sup>4Federal University of Pampa, Uruguaiana, Brazil..

<sup>4</sup>Federal University of Pampa, Uruguaiana, Brazil.

<sup>5</sup>Laboratory of Excitatory Amino Acids, National Institute of Neurology and Neurosurgery, Mexico City, Mexico..

<sup>6</sup>Federal University of Pampa, Uruguaiana, Brazil..

<sup>7</sup>Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Ks-158. Boston, MA.

<sup>8</sup>Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Cordoba, Cordoba, Spain.. fm2tufii@uco.es.
Conference/Journal: CNS Neurol Disord Drug Targets.
Date published: 2016 May 27
Other:
  Word Count: 162  
    Transcranial magnetic stimulation (TMS) is more than a mere tool for clinical non-invasive approaches to stimulate and synchronize the neuronal activity in the brain. Electromagnetic stimulation through TMS has recently emerged as a therapeutic alternative for treatment of different neurological disorders. Among the many properties recently discovered for TMS, its action as an accounting factor for neuroplasticity and neurogenesis is among its most promising features. Translational studies in animal models offer various advantages and also bridge this knowledge gap due to their direct assessment of the brain stimulation impact at the neural level. These profiles have been obtained through the study of animal models, which, in turn, have served for the establishment of the action mechanisms of this method. In this review we revise and discuss evidence collected on the promising properties of TMS after visiting the different animal models developed so far, and provide a practical perspective of its possible application for clinical purposes.



PMID: 27238155  [PubMed - as supplied by publisher]