Baseline biopsychosocial determinants of telomere length and 6-year attrition rate.


Author: Révész D, Milaneschi Y, Terpstra EM, Penninx BW

Affiliation: 1Department of Psychiatry, EMGO Institute for Health and Care Institute, VU University Medical Center, Amsterdam, the Netherlands. Electronic address: D.Revesz@ggzingeest.nl. 2Department of Psychiatry, EMGO Institute for Health and Care Institute, VU University Medical Center, Amsterdam, the Netherlands. Electronic address: Y.Milaneschi@ggzingeest.nl. 3Department of Psychiatry, EMGO Institute for Health and Care Institute, VU University Medical Center, Amsterdam, the Netherlands. Electronic address: E.M.Terpstra@student.vu.nl. 4Department of Psychiatry, EMGO Institute for Health and Care Institute, VU University Medical Center, Amsterdam, the Netherlands. Electronic address: B.Penninx@vumc.nl.
Conference/Journal: Psychoneuroendocrinology.
Date published: 2016 Feb 12
Other:
 Volume ID: 67   ,  Pages: 153-162   ,  Special Notes: doi: 10.1016/j.psyneuen.2016.02.007. [Epub ahead of print]   ,  Word Count: 251  
    BACKGROUND: Short leukocyte telomere length (TL) and accelerated telomere attrition have been associated with various deleterious health outcomes, although their determinants have not been explored collectively in a large-scale study.



MATERIAL AND METHODS: Leukocyte TL was measured (baseline N=2936; 6-year follow-up N=1860) in participants (18-65 years) from the NESDA study. Baseline determinants of TL included sociodemographics, lifestyle, chronic diseases, psychosocial stressors, and metabolic and physiological stress markers. Multivariate linear regression models were used to examine the associations between these determinants and (1) baseline TL, and (2) 6-year TL change. Multinomial logistic regression analyses were used to examine the predictors of telomere attrition and lengthening, as compared to stable TL.



RESULTS: Short baseline TL was associated with older age, male sex, non-European ethnicity, cigarette smoking, recent life events, and higher triglycerides, glucose and pre-ejection period (R2=11.3%). The 6-year telomere attrition was inversely associated with baseline TL (R2=51.6%); also older age, long sleep, not having a partner, high childhood trauma index, and gastrointestinal disease were associated with 6-year TL attrition (additional R2=3.7%). Telomere attrition seemed to have slightly more predictors than lengthening.



CONCLUSIONS: Sociodemographic, lifestyle, psychosocial stress and metabolic and physiological stress factors are cross-sectionally linked with TL. Telomere attrition over six years was strongly associated with baseline TL, suggesting an internal homeostatic influence. Modulation of the identified determinants may become target of future studies to promote telomere maintenance and healthy aging.



Copyright © 2016 Elsevier Ltd. All rights reserved.



KEYWORDS: Autonomic nervous system; Cortisol; Inflammation; Lifestyle; Metabolic syndrome; Telomeres

PMID: 26897704  [PubMed - as supplied by publisher]