The influence of oxidative stress induced by iron on telomere length.


Author: Kepinska M1, Szyller J2, Milnerowicz H3.

Affiliation: 1Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland. Electronic address: zalewska.m@gmail.com. 2Students Scientific Society at the Department of Biomedical Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland. 3Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.
Conference/Journal: Environ Toxicol Pharmacol. 
Date published: 2015 Oct 23
Other:
 Volume ID: 40   ,  Issue ID: 3   ,  Pages: 931-935   ,  Special Notes: doi: 10.1016/j.etap.2015.10.002   ,  Word Count: 127  
    Abstract

Oxidative stress can be induced by increased concentrations of iron in the body and consequently can cause shortening of telomeres. Telomeres, called mitotic clocks, are non-coding fragments at the end of chromosomes. During the replication of genetic material they are shortened, playing the role of ageing biomarkers in eukaryotes. In human endothelial cells, oxidative stress causes a decrease in telomerase activity. Shortening of chromosomes in telomeric parts was found in patients with primary hemochromatosis and in patients taking supplements containing iron. Increased level of transferrin saturation is associated with the presence of shorter telomeres in the chromosomes of leukocytes. The relationship between iron status and telomere length is still not fully understood.

Copyright © 2015 Elsevier B.V. All rights reserved.

KEYWORDS:

Iron; Oxidative stress; Telomere shortening

PMID: 26513689