Combined effects of flow-induced shear stress and electromagnetic field on neural differentiation of mesenchymal stem cells.


Author: Mascotte-Cruz JU1, Ríos A, Escalante B.

Affiliation: 1a Cinvestav Monterrey , Monterrey , Apodaca, N.L. , México.
Conference/Journal: Electromagn Biol Med.
Date published: 2015 Sep 1
Other:
  Pages: 1-5   ,  Word Count: 110  
    

Differentiation of bone marrow-derived mesenchymal stem cells (MSCs) into neural phenotype has been induced by either flow-induced shear stress (FSS) or electromagnetic fields (EMF). However, procedures are still expensive and time consuming. In the present work, induction for 1 h with the combination of both forces showed the presence of the neural precursor nestin as early as 9 h in culture after treatment and this result lasted for the following 6 d. In conclusion, the use of a combination of FSS and EMF for a short-time renders in neurite-like cells, although further investigation is required to analyze cell functionality.

KEYWORDS:

Extremely low-frequency electromagnetic fields; bone marrow-derived mesenchymal stem cells; fluid shear stress

PMID: 26325339