Music as an aid for postoperative recovery in adults: a systematic review and meta-analysis. Author: Hole J1, Hirsch M2, Ball E3, Meads C4. Affiliation: 1Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. 2BartsHealth NHS Trust, Whitechapel, London, UK. 3Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK; BartsHealth NHS Trust, Whitechapel, London, UK. Electronic address: elizabeth.ball@bartshealth.nhs.uk. 4Health Economics Research Group, Brunel University, Uxbridge, UK. Conference/Journal: Lancet Date published: 2015 Aug 12 Other: Pages: S0140-6736(15)60169-6 , Special Notes: doi: 10.1016/S0140-6736(15)60169-6 , Word Count: 275 BACKGROUND: Music is a non-invasive, safe, and inexpensive intervention that can be delivered easily and successfully. We did a systematic review and meta-analysis to assess whether music improves recovery after surgical procedures. METHODS: We included randomised controlled trials (RCTs) of adult patients undergoing surgical procedures, excluding those involving the central nervous system or head and neck, published in any language. We included RCTs in which any form of music initiated before, during, or after surgery was compared with standard care or other non-drug interventions. We searched MEDLINE, Embase, CINAHL, and Cochrane Central. We did meta-analysis with RevMan (version 5.2), with standardised mean differences (SMD) and random-effects models, and used Stata (version 12) for meta-regression. This study is registered with PROSPERO, number CRD42013005220. FINDINGS: We identified 4261 titles and abstracts, and included 73 RCTs in the systematic review, with size varying between 20 and 458 participants. Choice of music, timing, and duration varied. Comparators included routine care, headphones with no music, white noise, and undisturbed bed rest. Music reduced postoperative pain (SMD -0·77 [95% CI -0·99 to -0·56]), anxiety (-0·68 [-0·95 to -0·41]), and analgesia use (-0·37 [-0·54 to -0·20]), and increased patient satisfaction (1·09 [0·51 to 1·68]), but length of stay did not differ (SMD -0·11 [-0·35 to 0·12]). Subgroup analyses showed that choice of music and timing of delivery made little difference to outcomes. Meta-regression identified no causes of heterogeneity in eight variables assessed. Music was effective even when patients were under general anaesthetic. INTERPRETATION: Music could be offered as a way to help patients reduce pain and anxiety during the postoperative period. Timing and delivery can be adapted to individual clinical settings and medical teams. FUNDING: None. Copyright © 2015 Elsevier Ltd. All rights reserved. PMID: 26277246