Combination of music with lifestyle modification versus lifestyle modification alone on blood pressure reduction - A randomized controlled trial. Author: Kunikullaya KU1, Goturu J2, Muradi V2, Hukkeri PA2, Kunnavil R3, Doreswamy V2, Prakash VS4, Murthy NS5. Affiliation: 1Department of Physiology, M S Ramaiah Medical College and Group of Hospitals, Bangalore, Karnataka, India. Electronic address: kirthanaku@gmail.com. 2Department of Physiology, M S Ramaiah Medical College and Group of Hospitals, Bangalore, Karnataka, India. 3Department of Community Medicine, M S Ramaiah Medical College and Group of Hospitals, Bangalore, Karnataka, India. 4Department of Cardiology, M S Ramaiah Medical College and Group of Hospitals, Bangalore, Karnataka, India. 5Department of Division of Research and Patents, Gokula Education Foundation, Bangalore, Karnataka, India. Conference/Journal: Complement Ther Clin Pract. Date published: 2015 May 12 Other: Pages: S1744-3881(15)00043-2 , Special Notes: doi: 10.1016/j.ctcp.2015.05.004 , Word Count: 167 Abstract OBJECTIVE: To evaluate the change in blood pressure (BP) after 3 months of music intervention combined with lifestyle modifications, in comparison with conventional lifestyle modifications. METHODS: A Prospective randomized control trial was conducted on hundred prehypertensives or stage I hypertensives who were randomly divided into two groups (n = 50 each). Both the groups were given lifestyle modifications while one had added music intervention (raga bhimpalas) for 3 months. Main outcome measures were 24 h ambulatory BP monitoring, stress levels, and biomarkers of hypertension. RESULTS: Mean (SD) of diastolic BP (DBP) pre and post intervention were overall = 85.1(6.8) and 83(8.7){P = 0.004}, awake = 87.7(7.6) and 85.9(9.2){P = 0.021}. Regression analysis showed association between diastolic BP change and post-intervention stress score in the music intervention group. Significant change in BP was seen among those who were prehypertensives prior to intervention. CONCLUSION: Music decreased DBP and when used as an adjunct benefitted subjects with initial BP in prehypertension range. Copyright © 2015 Elsevier Ltd. All rights reserved. KEYWORDS: 24 h ambulatory blood pressure; Biomarkers hypertension; Indian music; Prehypertension; Stage I hypertension PMID: 26007202