Low-intensity pulsed ultrasound enhances bone formation around miniscrew implants.


Author: Ganzorig K1, Kuroda S2, Maeda Y1, Mansjur K1, Sato M1, Nagata K2, Tanaka E3.

Affiliation: 1Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Oral Sciences, Tokushima, Japan. 2Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan. 3Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan. Electronic address: etanaka@tokushima-u.ac.jp.
Conference/Journal: Arch Oral Biol
Date published: 2015 Mar 4
Other:
 Volume ID: 60   ,  Issue ID: 6   ,  Pages: 902-910   ,  Special Notes:  doi: 10.1016/j.archoralbio.2015.02.014.   ,  Word Count: 208  
    Abstract

Miniscrew implants (MSIs) are currently used to provide absolute anchorage in orthodontics; however, their initial stability is an issue of concern. Application of low-intensity pulsed ultrasound (LIPUS) can promote bone healing. Therefore, LIPUS application may stimulate bone formation around MSIs and enhance their initial stability.

AIM:

To investigate the effect of LIPUS exposure on bone formation after implantation of titanium (Ti) and stainless steel (SS) MSIs.

METHODS:

MSIs made of Ti-6Al-4V and 316L SS were placed on rat tibiae and treated with LIPUS. The bone morphology around MSIs was evaluated by scanning electron microscopy and three-dimensional micro-computed tomography. MC3T3-E1 cells cultured on Ti and SS discs were treated with LIPUS, and the temporary expression of alkaline phosphatase (ALP) was examined.

RESULTS:

Bone-implant contact increased gradually from day 3 to day 14 after MSI insertion. LIPUS application increased the cortical bone density, cortical bone thickness, and cortical bone rate after implantation of Ti and SS MSIs (P<0.05). LIPUS exposure induced ALP upregulation in MC3T3-E1 cells at day 3 (P<0.05).

CONCLUSION:

LIPUS enhanced bone formation around Ti and SS MSIs, enhancing the initial stability of MSIs.

Copyright © 2015 Elsevier Ltd. All rights reserved.

KEYWORDS:

Bone formation; Low-intensity pulsed ultrasound; Miniscrew implant; Stainless steel; Titanium

PMID: 25824309