Modern genome editing meets telomeres: the many functions of TPP1.


Author: Karlseder J.

Affiliation: The Salk Institute, La Jolla, California 92037, USA karlseder@salk.edu.
Conference/Journal: Genes Dev.
Date published: 2014 Sep 1
Other:
 Volume ID: 28   ,  Issue ID: 17   ,  Pages: 1857-1858   ,  Word Count: 69  
    Abstract

The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis.

© 2014 Karlseder; Published by Cold Spring Harbor Laboratory Press.

KEYWORDS:

embryonic stem cells; human genome engineering; shelterin; telomerase; telomere maintenance



PMID: 25184673